Epigenetic Mechanisms Involved in the Cardiovascular Toxicity of Anticancer Drugs
نویسندگان
چکیده
منابع مشابه
Epigenetic mechanisms of plant-derived anticancer drugs.
Epigenetic mechanisms are essential for normal development and maintenance of adult life. Disruption of epigenetic processes results in deregulated gene expression and leads to life-threatening diseases, in particular, cancer. Global epigenetic alterations are a hallmark of cancer. Cancer epigenetics revealed the deregulation of all components of the epigenetic machinery including DNA methylati...
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Transcriptional dysregulation is an early event and may be an important pathological mechanism in Huntington's disease (HD). However, the exact process that leads to alterations in gene expression in HD is not clear. One potential mechanism underlying transcriptional abnormalities in HD may be epigenetic alterations which regulate gene expression without changing the DNA sequence. Previous work...
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The management of cancer involves surgery, radiotherapy and chemotherapy. Development of chemoresistance is a persistent problem during the chemotherapy treatment. Cytotoxic drugs that selectively, but not exclusively, target actively proliferating cells include such diverse groups as DNA-alkylating agents, anti-metabolites, intercalating agents and mitotic inhibitors. Resistance constitutes a ...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2021
ISSN: 2297-055X
DOI: 10.3389/fcvm.2021.658900